Protein interactions in inflammatory diseases
Inflammation is part of the body's natural response to an infection or injury. Classic symptoms of an infection include swelling, redness, warmth and tenderness.
The symptoms are caused by a series of physiological processes that are started when a stimuli triggers an intracellular pathway. This in turn leads to an activation of genes, intracellular proteins and protein complexes. Mutations in these proteins can cause changes in the immunological response and thereby a variety of chronic inflammatory diseases.
The objective of the project is to obtain a better picture of how the proteins in these signalling pathways and protein complexes interact with each other in order to understand the onset of inflammatory diseases and how they can be treated.