Sandra Karlsson

Research interest

"Expression analysis of Genes involved in the Development of Adenocarcinomas in a rat model of Human Endometrial Cancer" -The research project aims to identify pathways of gene interaction during cancer development on both the genomic and the translational levels in a rat model of human endometrial adenocarcinoma.By means of cDNA microarrays, weare performinggene expression profiling(in collaboration with Swegene DNA Microarray Resource Centre). Furthermore, in the microarray analysis we also compare expression patterns in endometrial neoplasiaat different stages.The genomic analysisin the projectis performed by Fredrik Trossöand involvesCGH-microarrays.

Teaching

Besides my research, I'm also busy with teachingin several courses at our department. Some of the courses are:

• Tumour Biology
• Human Genetics
• General Biomedicine
• Genomics
• ExperimentalDesign
• Project works in biomedicine
• Supervisorof honour studentsin biomedicine
• Program director of the international one year master programin Biomedicine

Other activities

• Member of the Committee ofCoordinated Research Studies at University of Skövde (2005-2006).
• PhD student representative in the department board (2005).
• Chairmanof the PhD student association at Schoolof Life Sciences, University of Skövde(2005).
• PhD student representative in the board of the research school in genomics andbioinformatics (2005/2006).
• PhD student representative inFUN (faculty board)atUniversity of Skövde (2006-2007).
• PhDstudent representative in theboard of research and higher education at University of Skövde (2006-2007).
• PhD student representative in "Rådet för docentprövning" (2007)

• Fagerlind, M., Nilsson, P., Harlén, M., Karlsson, S., Rice, S. and Kjelleberg, S. (2005).Modeling the effect of acylated homoserine lactone antagonists in Pseudomonas aeruginosa.Biosystems. 80(2): 201-213.
• Karlsson Sandra (2006). Expression analysis of genes involved in the development of endometrial adenocarcinoma in rat model of human cancer. Göteborg University, Göteborg. ISBN: 91-631-8748-5.
• Carola Nordlander, Sandra Karlsson, Åsa Karlsson, Åsa Sjöling, Marta Vinnaes, Karin Klinga-Levan, and Afrouz Behboudi. (2007). Analysis of chromosome 10 aberrations in rat endometrial cancer – evidence for a tumor suppressor locus distal to Tp53. International Journal of Cancer. 120(7): 1472-1481.

• Karlsson, S. and Klinga-Levan, K. (In press). Expression analysis of genes involved in EAC carcinogenesis in a rat model of human endometrial cancer. Hormonal Carcinogenesis, Springer Verlag.

• Karlsson, S., Holmberg, E., Askerlind, A., Klinga Levan, K. (2007). Altered transforming growth factor-beta pathway expression pattern in rat endometrial cancer. Cancer Genetics and Cytogenetics. 177: 43-50