| 19/1 |
| Diskussionsledare: Mikael Ejdebäck and Andreas Jansson |
Under seminariediskussionen diskuterar vi följande: • Sett i backspegeln, hur har miljön fungerat och hur vill vi att den ska fungera i framtiden
• Vilka gemensamma projekt och ansökningar finns och planeras
• Vilka gemensamma aktivitetet finns och planeras |
| 16/2 |
| Speaker: Kristina Sundell, Professor i Zoologi, Göteborgs universitet |
| Title: Ussing chambers - the ultimate tool to study epithelial physiology!? |
| 2/3 |
| Speaker: Heidi Paltto |
| Title: Conservation Ecology in Oak-rich Forests |
Abstract: I will talk about the local biodiversity in oak-rich forests and how this is affected by forest succession, partial cutting and the amount of deciduous forest in the surrounding landscape at various spatio-temporal scales. I will also talk about indicator species and how well they work in oak-rich forests. My talk will be on my PhD-studies in Gothenburg, a minor project thereafter, and my current work here at HiS. |
| 16/3 |
| Diskussionsledare: Mikael Ejdebäck and Andreas Jansson |
Under seminariediskussionen behandlar vi följande: • Hur marknadsför vi oss nationellt och internationellt som forskningsmiljö
• Hur samarbetar/samverkar vi med andra lärosäten när det gäller forskning, kurser, program och doktorander
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| 27/4 |
| Speaker: Jessica Carlsson |
| Title: Investigating the correlation between miRNA expression and clinical stage, grade and outcome of prostate cancer |
Abstract: Prostate cancer is the most common cancer in men in Sweden. During 2007, 8 870 new cases was diagnosed which made up 35 % of all cancer cases in men. The detection of prostate cancer is partly made by measuring prostate specific antigen (PSA), a protein specifically produced by the cells in the prostate gland. An increased PSA value can be an indicator of prostate cancer but it can also be due to other diseases such as a benign hyperplasia or inflammation in the prostate.
MicroiRNAs (miRNA) is a small class of non protein coding RNAs of 18-22 nucleotides. Since the discovery of the first miRNA in C. elegans by Victor Ambrose and colleagues in 1993, a wide range of miRNAs has been found both in plants, animals and fungus. The role of miRNAs is to regulate gene expression by inhibiting translation, cleavage of mRNA or methylation of DNA. Studies have shown that a miRNA profile can be used to separate tumors according to developmental origin, differentiation and underlying genetic abnormality.
This study aims to find a miRNA profile that discriminate between normal and cancerous tissues in prostate cancer. Ultimately the aim is to find a set of miRNAs that can be used as markers for diagnosis, clinical stage, grade and outcome. Contact persons: Karin Klinga Levan, Björn Olsson, Jessica Carlsson. |
| 11/5 |
| Speaker: Karin Klinga Levan, Professor i biomedicin |
| Subject: Nydisputerad, vad händer sedan? |
| 25/5 |
| Speaker: Joshi, M., Orenic, T. |
| Title: Spatial regulation of proneural gene expression in the Drosophila Peripheral Nervous System |
Abstract: The stereotypical arrangement of sensory bristles on the legs of the
Drosophila adult provides a good model system to study pattern formation during
development. The leg exhibits a precise pattern of small sensory bristles or microchaete (mC), in eight straight longitudinal rows. The proneural gene, achaete (ac), is expressed in longitudinal stripes, which comprise the leg microchaete (mC) primordia. We have previously shown that this organization requires the position-specific expression of two genes: the proneural gene achaete(ac) and hairy, which encodes a transcriptional repressor of ac. We have identified Delta (Dl), which encodes a Notch (N) ligand, as a second leg prepattern gene required to establish periodic ac expression. We show that, Hairy and Dl function concertedly and nonredundantly to define periodic ac expression.
Our findings have allowed us to formulate a general model for generation of a periodic bristle pattern in the adult leg. This process involves broad and late activation of ac expression combined with refinement in response to a prepattern of repression, established by Hairy and Dl. This prepattern of repression, unfolds progressively during larval and early prepupal stages of development. Our model is supported by the analysis of an enhancer that specifically directs ac expression in the leg microchaete proneural fields and is spatially and temporally regulated. This enhancer contains a small activation element, which directs broad expression of ac along the leg circumference, and is associated with two repression elements, one that is Dl/N-responsive and another that is Hairy-responsive.
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