CV
Forskningsprojekt
1. Studier av vitamin D systemets reglering av tarmens kalciumtransport, med målsättning att karakterisera de aktiva vitamin D metabioliternas (1,25-dihydroxyvitamin D3 och 24,25-dihydroxyvitamin D3) signalvägar och verkningsmekanismer i tarmens kalciumtransporterande celler.
Studies on the function of the vitamin D endocrine system in regulating intestinal calcium transport, with the emphasis to characterize the signal transduction pathways and the underlying mechanisms for two vitamin D metabolites, 1,25-dihydroxyvitamin D3 och 24,25-dihydroxyvitamin D3.
2. Studier av vitamin D systemets reglering av prostatacellers tillväxt och differentiering, med syfte att karakterisera verkningsmekanismerna bakom 1,25-dihydroxyvitamin D3 tillväxthämmande effekter på prostatacancer celler.
Studies on vitamin D-dependent regulation of growth and differentiation of prostate cells, with the emphasis on to reveale the basic mechanisms underlying the role of 1,25-dihydroxyvitamin D3 in regulation of prostate cell differentiation, proliferation and apoptosis
Publications
Larsson, D., Björnsson, B. Th. and Sundell, K. (1995). Physiological concentrations of 24,25-dihydroxy vitamin D3 rapidly decrease the in vitro intestinal calcium uptake in the Atlantic cod, Gadus morhua. Gen. Comp. Endocrinol. 100, 211-217.
Larsson, D., Lundgren, T. and Sundell, K. (1998). Ca2+ uptake through voltage-gated L-type Ca2+ channels by polarized enterocytes from Atlantic cod Gadus morhua. J Membrane Biol 164, 229-237.
Larsson, D., Larsson, B., Lundgren, T. and Sundell, K. (1999). The effect of pH and temperature on the dissociation constant for fura-2, and their effects on [Ca2+]i in enterocytes from a poikilothermic animal, Atlantic cod (Gadus morhua). Anal. Biochem. 273, 60-65.
Nemere, I., Larsson, D. and Sundell, K. (2000). A specific binding moiety for 1,25-dihydroxyvitamin D3 in basal lateral membranes of carp enterocytes. Am. J. Physiol. 279, E614-E621.
Larsson, D., Nemere, I. and Sundell, K. (2001). Putative basal lateral membrane receptors for 24,25-dihydroxyvitamin D3 in carp and Atlantic cod enterocytes: characterization of binding and effects on intracellular calcium regulation. J Cell Biochem. 83, 171-186.
Larsson, D., Aksnes, L., Björnsson B. Th., Larsson, B., Lundgren T. and Sundell, K. (2002). Antagonistic effects of 24R,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 on L-type Ca2+ channels and Na+/Ca2+ exchange in enterocytes from Atlantic cod (Gadus morhua). J Molec Endocrinol. 28(1), 53-68.
Nemere, I., Atkinson, D. Y., Johns, D. O. and Larsson, D. (2002). Biochemical characterization and purification of a binding protein for 24,25-dihydroxyvitamin D3 from chick intestine. J. Endocrinol. 172(1), 211-219.
Boyan, B.D., Bonewald, L.F., Sylvia, V.L., Nemere, I., Larsson, D., Norman, A.W., Rosser, J., Dean, D.D. and Schwartz, Z. (2002). Evidence for distinct membrane receptors for 1,25-(OH)2D3 and 24R,25-(OH)2D3 in Osteoblasts. Steroids 67(3-4), 235-246.
Schwartz, Z., Sylvia, V. L., Larsson, D., Nemere, I., Casasola, D., Dean, D. D. and Boyan, B. D. (2002). 1,25-(OH)2D3 regulates chondrocyte matrix vesicle protein kinase C directly via G-protein dependent mechanisms and indirectly via incorporation of PKC during matrix vesicle biogenesis. J Biol Chem.277(14), 11828-11837.
Schwartz, Z., Ehland, H., Sylvia, V. L., Larsson, D., Hardin, R., Bingham, V., Lopez, D., Dean, D. D. and Boyan, B. D. (2002) 1,25-(OH)2D3 and 24R,25-(OH)2D3 modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. Endocrinology 143: 2775-2786.
Larsson, D., Nemere, I., Aksnes, L. and Sundell, K. (2003). Environmental Salinity regulates receptor expression, cellular effects and circulating levels of two antagonizing hormones, 1,25(OH)2D3 and 24,25(OH)2D3, in rainbow trout. Endocrinology.144(2): 559-566.
Larsson, D., Anderson, D., Smith, N.M. and Nemere, I. (2006). 24,25-dihydroxyvitamin D3 binds to catalase. J Cell Biochem 97:1259-1266.
Reviews and Book chapters
Sundell, K., Larsson, D. and Björnsson, B. Th. (1996). The calcium regulatory role of the vitamin D3-system in teleosts. In The comparative endocrinology of calcium regulation. Editors: C. Dacke, J. Danks, I. Caple and G. Flik. Society for Endocrinology. p 75-84.
Björnsson, B. Th., Persson, P., Larsson, D., Jóhannsson, S. H. and Sundell, K. (1999). Calcium balance in teleost fish: endocrine control and physiological mechanisms. In The comparative endocrinology of calcium regulation. Editors: J. Danks, C. Dacke, G. Flik and C. Gay. Society for Endocrinology. p 29-38.
Larsson, D., Ph. D. Dissertation. (1999). Vitamin D in teleost fish: Non-genomic regulation of intestinal calcium transport (dissertation: ISBN-91-628-3681-1).
Larsson, D., and Nemere, I. (2001). 24,25-dihydroxyvitamin D3 and intestinal calcium transport: from receptors to physiological response. Recent Research Developments in Endocrinology. Editor: S.G. Pandalai. Transworld research Network. Vol 2(1), p 183-198.
Nemere, I., and Larsson, D. (2002). Does PTH have a direct effect on intestine? J Cell Biochem. 86: 29-34.
Larsson, D., and Nemere, I. (2002). Vectorial transcellular calcium transport in intestine: Integration of current models. J Biomedicine and Biotechnol. Vol 2(3), p 117-119.
Larsson, D., Sundell, K., Larsson, B., and Nemere, I. (2002). Enterocyte calcium uptake and extrusion: transport mechanisms and endocrine regulation. Recent Research Developments in Membrane Biology. Editor: S.G. Pandalai. Transworld research Network. Vol 1, p 61-74.