HPV - a major cause of prostate cancer

In this study, the prevalence of HPV infection in patients with prostate cancer of different pathological grades was investigated.

The study entitled “Implication of high risk Human papillomavirus HR-HPV infection in prostate cancer in Indian population- A pioneering case-control analysis” by Dr. Neha Singh and co-authors was published in the peer reviewed journal Nature Scientific Reports (www.nature.com/srep) on 16 January, 2015. In this study, the prevalence of HPV infection in patients with prostate cancer of different pathological grades was investigated.

This is a pioneering study that represents the incidence of HPV infection in prostate cancer in Indian population and strengthens the hypothesis that HPV infection could be one of the co factors associated with progression of prostate cancer. In the previous studies the group has reported a strong association of the oncogenic HPV types 16 and 18 with cervical cancer. It has been speculated that cervical and prostate cancer may represent, in some aspects, homologous cancers in females and males, respectively. Both of the cancer types are influenced by similar factors like sexual activities and infection status with a roughly equal lifetime risk.

There is a growing evidence of the role of the sexually transmitted diseases in prostate cancer. Therefore, it is possible that there would be an association between oncogenic HPV infection and prostate cancer. HPV infection may throw some light on the recent increase in the incidence of prostate cancer in men. The young men once exposed to HPV infection, it initiates a chain of host genetic transformation that can eventually lead to cancer decades later. The prevalence of high risk HPV type 16 DNA in prostate cancer cases indicated a potential association between HPV infection and prostate cancer risk.

The present study guarantees the clinical relevance of HPV infection in prostate carcinogenesis; therefore, screening of young men with these HPV types may play a vital role in curing the cancer progression. This study is of tremendous importance as the availability of HPV vaccines may guarantee indispensable prevention of HPV viral infection that may play a critical role in causing prostate cancer.

About us in the media

 

Projectleader

The project in short

Full name of project:
Implication of high risk Human papillomavirus HR-HPV infection in prostate cancer in Indian population- A pioneering case-control analysis

Durance:
2 years

Financed by:
Department of Biotechnology, Government of India.

Collaborating partners/Partnership:
Division of Molecular Genetics and Biochemistry, Institute of Cytology and Preventive Oncology (ICMR), NOIDA, India
Post Graduate Institute of Medical Education and Research, Chandigarh, India

Researchers related to the current project

Prof RC Sobti: Department of Biotechnology, Panjab University, Chandigarh, India.

Dr Mausumi Bharadwaj and Dr Showket Hussain: Institute of Cytology and Preventive Oncology (Indian Council of Medical Research), NOIDA, India.