School of Bioscience
My research mainly focuses on the use of mathematical, computational and statistical methods and models in the area of infection biology. In recent years, my research has been directed more towards translational medicine, especially in development and application of data-mining methods on large-scale biomarker data. Although that the advent of high-throughput technologies capable of producing large-scale biological data has provided an excellent opportunity for the discovery of novel biomarkers, it has simultaneously complicated the problem of mining meaningful biomarker signatures as analysis and interpretation of such complex data require sophisticated systems biology approaches.
My ongoing research aims at developing accurate and transparent diagnosis support systems for early identification of patients with bacterial sepsis, and includes the projects Data-mining for biomarker discovery, selection, and validation (2017-2021, Knowledge Foundation), Next generation sepsis diagnosis (2016-2021, EU, H2020), Development of sepsis diagnosis system (2016-2019, Knowledge Foundation), and Microbial diversity in patients suspected with sepsis (financed through several research grants). Current research collaborators include Skaraborg Hospital, Unilabs AB, TATAA Biocenter AB, Gothenburg University, bioMérieux Sweden AB, 1928Diagnostics AB, Olink Proteomics AB, QIAGEN AB, Danska Tekniska Universitetet, Copenhagen Business School, Charles University, Danube University, Deutsches Institut fur Normung, CubeDx, and Zoetis.
I gained my master degree in Molecular Computational Biology from University of Skövde in 2004, and I defended my PhD, entitled “Studies on emergence and spread of antibiotic resistant Streptococcus pneumoniae”, at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet in 2010. Currently, I´m a Senior Lecturer in Systems Biology, Head of Systems Biology, a member of the Infection Biology Group and the Systems Biology Research Centre at the University of Skövde.
Evaluation of QuickFISH and maldi Sepsityper for identification of bacteria in bloodstream infectionEnroth Helena, Retz Karolina, Andersson Sofie et al.Infectious Diseases, 2019, 51(4), 249-258.
MicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnosticsDave Vivek Priy, Ngo Tien Anh, Pernestig Anna-Karin et al.Laboratory Investigation, 2018, 99(4), 452-469.
Diagnostic accuracy of procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein, and lactate in patients with suspected bacterial sepsisLjungström Lars, Pernestig Anna-Karin, Jacobsson Gunnar et al.PLoS ONE, 2017, 12(7).
Evaluation of the QuickFISH and the Sepsityper assays for early identification of etiological agents in bloodstream infection in a clinical routine setting
Retz Karolina, Andersson Sofie, Andersson Carl et al.27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Vienna, Austria, 22 – 25 April 2017. 2017.
Ny metod bedömer risk för bomullsmögel
Wallenhammar Ann-Charlotte, Algerin Maria, Tilevik DianaArvensis, 2017(3).
The diagnostic value of PCT as biomarker in patients suspected with community-onset bacterial sepsis
Ljungström Lars, Jacobsson Gunnar, Pernestig Anna-Karin et al.European Congress of Clinical Microbiology and Infectious Diseases. ECCMID, 2017.
Towards a Clinical Support System for the Early Diagnosis of Sepsis
Helldin Tove, Pernestig Anna-Karin, Tilevik DianaDigital Human Modeling - Applications in Health, Safety, Ergonomics, and Risk Management: Health and Safety: 8th International Conference, DHM 2017 Held as Part of HCI International 2017 Vancouver, BC, Canada, July 9–14, 2017, Proceedings, Part II (23-35). Springer, 2017.
Long-term effects of penicillin resistance and fitness cost on pneumococcal transmission dynamics in a developed settingTilevik DianaInfection Ecology & Epidemiology, 2016, 6.
Clinical evaluation of commercial nucleic acid amplification tests in patients with suspected sepsisLjungström Lars, Enroth Helena, Claesson Berndt E. B. et al.BMC Infectious Diseases, 2015, 15(1).
Multimarker approach for sepsis diagnostics
Karlsson Diana, Pernestig Anna-Karin, Ljungström Lars25th European Congress of Clinical Mircobiology and Infectious Diseases, Copenhagen, April 25-28, 2015. European Society of ClinicalMicrobiology and Infectious Diseases (ESCMID), 2015.