Peter Sartipy

Data Mining Identifies CCN2 and THBS1 as Biomarker Candidates for Cardiac Hypertrophy

Markus Johansson, Benyapa Tangruksa, Sepideh Heydarkhan-Hagvall, Anders Jeppsson, Peter Sartipy, Jane Synnergren

Life

2022. Article. https://doi.org/10.3390/life12050726 Open Access

Multi-Omics Characterization of a Human Stem Cell-Based Model of Cardiac Hypertrophy

Markus Johansson, Benjamin Ulfenborg, Christian X. Andersson, Sepideh Heydarkhan-Hagvall, Anders Jeppsson, Peter Sartipy, Jane Synnergren

Life

2022. Article. https://doi.org/10.3390/life12020293 Open Access

Unraveling the Metabolic Derangements Occurring in Non-infarcted Areas of Pig Hearts With Chronic Heart Failure

Cláudia Correia, Qing-Dong Wang, Gunilla Linhardt, Leif G. Carlsson, Benjamin Ulfenborg, Anna Walentinsson, Katarina Rydén-Markinhutha, Margareta Behrendt, Johannes Wikström, Peter Sartipy, Karin Jennbacken, Jane Synnergren

Frontiers in Cardiovascular Medicine

2021. Article. https://doi.org/10.3389/fcvm.2021.753470 Open Access

Heart failure drug titration, discontinuation, mortality and heart failure hospitalization risk: a multinational observational study (US, UK and Sweden)

Gianluigi Savarese, Johan Bodegard, Anna Norhammar, Peter Sartipy, Marcus Thuresson, Martin R. Cowie, Gregg C. Fonarow, Muthiah Vaduganathan, Andrew J. S. Coats

European Journal of Heart Failure

2021. Article. https://doi.org/10.1002/ejhf.2271 Open Access

Data from a pooled post hoc analysis of 14 placebo-controlled, dapagliflozin treatment studies in patients with type 2 diabetes with and without anemia at baseline

Bergur V. Stefánsson, Hiddo J. L. Heerspink, David C. Wheeler, C. David Sjöström, Peter J. Greasley, Peter Sartipy, Valerie Cain, Ricardo Correa-Rotter

Data in Brief

2021. Article. https://doi.org/10.1016/j.dib.2021.107237 Open Access

Multi-Assignment Clustering: Machine learning from a biological perspective

Benjamin Ulfenborg, Alexander Karlsson, Maria Riveiro, Christian X. Andersson, Peter Sartipy, Jane Synnergren

Journal of Biotechnology

2021. Article. https://doi.org/10.1016/j.jbiotec.2020.12.002 Open Access

Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver Tissue

Nidal Ghosheh, Barbara Küppers-Munther, Annika Asplund, Christian X. Andersson, Petter Björquist, Tommy B. Andersson, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren

ACS Omega

2020. Article. https://doi.org/10.1021/acsomega.9b03514 Open Access

Cardiac hypertrophy in a dish: a human stem cell based model

Markus Johansson, Benjamin Ulfenborg, Christian X. Andersson, Sepideh Heydarkhan-Hagvall, Anders Jeppsson, Peter Sartipy, Jane Synnergren

Biology open

2020. Article. https://doi.org/10.1242/bio.052381 Open Access

The effects of dapagliflozin on cardio-renal risk factors in patients with type 2 diabetes with or without renin-angiotensin system inhibitor treatment: a post hoc analysis

Rosalie A. Scholtes, Daniël H. van Raalte, Ricardo Correa-Rotter, Robert D. Toto, Hiddo J. L. Heerspink, Valerie Cain, C. David Sjöström, Peter Sartipy, Bergur V. Stefánsson

Diabetes, obesity and metabolism

2020. Article. https://doi.org/10.1111/dom.13923 Open Access

Correction of anemia by dapagliflozin in patients with type 2 diabetes

Bergur V. Stefánsson, Hiddo J. L. Heerspink, David C. Wheeler, C. David Sjöström, Peter J. Greasley, Peter Sartipy, Valerie Cain, Ricardo Correa-Rotter

Journal of diabetes and its complications

2020. Article. https://doi.org/10.1016/j.jdiacomp.2020.107729

Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models

Cecilia Granéli, Ryan Hicks, Gabriella Brolén, Jane Synnergren, Peter Sartipy

Stem Cell Reviews

2019. Article. https://doi.org/10.1007/s12015-018-9858-1 Open Access

Reduction in albuminuria with dapagliflozin cannot be predicted by baseline clinical characteristics or changes in most other risk markers

Hiddo J. L. Heerspink, C. David Sjöström, Silvio E. Inzucchi, Melissa K. Hallow, Valerie A. Cain, Peter Rossing, Bergur V. Stefansson, Peter Sartipy

Diabetes, obesity and metabolism

2019. Article. https://doi.org/10.1111/dom.13579 Open Access

Correction of hypomagnesemia by dapagliflozin in patients with type 2 diabetes: A post hoc analysis of 10 randomized, placebo-controlled trials

Robert D. Toto, Ronald Goldenberg, Glenn M. Chertow, Valerie Cain, Bergur V. Stefánsson, Carl David Sjöström, Peter Sartipy

Journal of diabetes and its complications

2019. Article. https://doi.org/10.1016/j.jdiacomp.2019.06.007

Efficacy and safety of dapagliflozin in patients with type 2 diabetes and moderate renal impairment (chronic kidney disease stage 3A): The DERIVE Study

Paola Fioretto, Stefano Del Prato, John B. Buse, Ronald Goldenberg, Francesco Giorgino, Daniel Reyner, Anna Maria Langkilde, C. David Sjöstrom, Peter Sartipy

Diabetes, obesity and metabolism

2018. Article. https://doi.org/10.1111/dom.13413 Open Access

Expression profiling of human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin - integration and visualization of multi omics data

Gustav Holmgren, Peter Sartipy, Christian X. Andersson, Anders Lindahl, Jane Synnergren

Toxicological Sciences

2018. Article. https://doi.org/10.1093/toxsci/kfy012

Dapagliflozin in patients with type II diabetes mellitus, with and without elevated triglyceride and reduced high-density lipoprotein cholesterol levels

Harold E. Bays, Peter Sartipy, John Xu, Carl David Sjöström, James A. Underberg

Journal of Clinical Lipidology

2017. Article. https://doi.org/10.1016/j.jacl.2017.01.018

Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue

Nidal Ghosheh, Barbara Küppers-Munther, Annika Asplund, Josefina Edsbagge, Benjamin Ulfenborg, Tommy B. Andersson, Petter Björquist, Christian X. Andersson, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren

Physiological Genomics

2017. Article. https://doi.org/10.1152/physiolgenomics.00007.2017 Open Access

Visual integration of multiple omics data from human pluripotent stem cell-derived cardiomyocytes

Peter Sartipy, Gustav Holmgren, Jane Synnergren, Christian Andersson, Anders Lindahl

International Society for Stem Cell Research (ISSCR) Annual meeting, Boston 14–17 June 2017

2017. Conference paper, poster.

A data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells

Benjamin Ulfenborg, Alexander Karlsson, Maria Riveiro, Caroline Améen, Karolina Åkesson, Christian X. Andersson, Peter Sartipy, Jane Synnergren

PLOS ONE

2017. Article. https://doi.org/10.1371/journal.pone.0179613 Open Access

One Standardized Differentiation Procedure Robustly Generates Homogenous Hepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells

Annika Asplund, Arvind Pradip, Mariska van Giezen, Anders Aspegren, Helena Choukair, Marie Rehnström, Susanna Jacobsson, Nidal Ghosheh, Dorra El Hajjam, Sandra Holmgren, Susanna Larsson, Jörg Benecke, Mariela Butron, Annelie Wigander, Karin Noaksson et al.

Stem Cell Reviews

2016. Article. https://doi.org/10.1007/s12015-015-9621-9

Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines

Nidal Ghosheh, Björn Olsson, Josefina Edsbagge, Barbara Küppers-Munther, Mariska Van Giezen, Annika Asplund, Tommy B. Andersson, Petter Björquist, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren

Stem Cells International

2016. Article. https://doi.org/10.1155/2016/8648356 Open Access

MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity

Gustav Holmgren, Jane Synnergren, Christian X. Andersson, Anders Lindahl, Peter Sartipy

Toxicology in Vitro

2016. Article. https://doi.org/10.1016/j.tiv.2016.03.009

High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge

Stem Cells International

2016. Article. https://doi.org/10.1155/2016/2475631 Open Access

Interactive visualization of large-scale gene expression data

Maria Riveiro, Mikael Lebram, Christian X. Andersson, Peter Sartipy, Jane Synnergren

Information Visualisation: Computer Graphics, Imaging and Visualisation

2016. Conference paper. https://doi.org/10.1109/IV.2016.58

Transcriptional profiling of human embryonic stem cells during mesodermal- and cardiac differentiation

Jane Marie Synnergren, Caroline Améen, Karolina Åkesson, Alexander Karlsson, Maria Riveiro, Christian X. Andersson, Peter Sartipy

International Society for Stem Cell Research (ISSCR) Annual meeting, San Fransisco 22–25 June 2016

2016. Conference paper, poster.

Comparative transcriptomic analysis identifies genes differentially expressed in human epicardial progenitors and hiPSC-derived cardiac progenitors

Jane Synnergren, Lauren Drowley, Alleyn T. Plowright, Gabriella Brolén, Marie-Josè Goumans, Adriana C. Gittenberger-de Groot, Peter Sartipy, Qing-Dong Wang

Physiological Genomics

2016. Article. https://doi.org/10.1152/physiolgenomics.00064.2016 Open Access

Identification of stable reference genes in differentiating human pluripotent stem cells

Gustav Holmgren, Nidal Ghosheh, Xianmin Zeng, Yalda Bogestål, Peter Sartipy, Jane Synnergren

Physiological Genomics

2015. Article. https://doi.org/10.1152/physiolgenomics.00130.2014

Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells

Gustav Holmgren, Jane Synnergren, Yalda Bogestål, Caroline Améen, Karolina Åkesson, Sandra Holmgren, Anders Lindahl, Peter Sartipy

Toxicology

2015. Article. https://doi.org/10.1016/j.tox.2014.12.018 Open Access

Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters

Angelika Kunze, Daniella Steel, Kerstin Dahlenborg, Peter Sartipy, Sofia Svedhem

PLOS ONE

2015. Article. https://doi.org/10.1371/journal.pone.0125540 Open Access

Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes

Gustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson, Josefina Edsbagge

Drug Metabolism And Disposition

2014. Article. https://doi.org/10.1124/dmd.114.059154

Employment of the Triple Helix concept for development of regenerative medicine applications based on human pluripotent stem cells

Peter Sartipy, Petter Björquist

Clinical and translational medicine

2014. Article, review. https://doi.org/10.1186/2001-1326-3-9 Open Access

Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue

Jane Synnergren, Caroline Améen, Andreas Jansson, Peter Sartipy

Physiological Genomics

2012. Article. https://doi.org/10.1152/physiolgenomics.00118.2011

Transcriptional analysis of messenger-RNA and micro-RNA array data reveals global negative correlation in human stem cell derived cardiomyocyte clusters

Jane Synnergren, Peter Sartipy

4th International Conference on Bioinformatics and Computational Biology

2012. Conference paper.

Expression of microRNAs and their target mRNAs in human stem cell-derived cardiomyocyte clusters and in heart tissue

Jane Synnergren, Caroline Améen, Anders Lindahl, Björn Olsson, Peter Sartipy

Physiological Genomics

2011. Article. https://doi.org/10.1152/physiolgenomics.00074.2010

Microarray Analysis of Undifferentiated and Differentiated Human Pluripotent Stem Cells

Jane Synnergren, Peter Sartipy

Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications

2011. Chapter in book.

Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further towards the hepatic lineage

Jane Synnergren, Nico Heins, Gabriella Brolén, Gustav Eriksson, Anders Lindahl, Johan Hyllner, Björn Olsson, Peter Sartipy, Petter Björnquist

Stem Cells and Development

2010. Article. https://doi.org/10.1089/scd.2009.0220

Clustering micro-RNA array data using an information fusion based approach with multiple types of input data

Jane Synnergren, Alper Özdogan, Björn Olsson, Peter Sartipy

Proceedings of the ISCA 2nd International Conference on Bioinformatics and Computational Biology, BICoB-2010, March 24-26, 2010, Sheraton Waikiki Hotel, Honolulu, Hawaii, USA

2010. Conference paper.

Cardiomyogenic gene expression profiling of differentiating human embryonic stem cells

Jane Synnergren, Sudeshna Adak, Mikael Englund, Theresa Giesler, Karin Noaksson, Anders Lindahl, Patric Nilsson, Deirdre Nelson, Stewart Abbot, Björn Olsson, Peter Sartipy

Journal of Biotechnology

2008. Article. https://doi.org/10.1016/j.jbiotec.2007.11.011

Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells

Jane Synnergren, Karolina Åkesson, Kerstin Dahlenborg, Hilmar Vidarsson, Caroline Ameen, Daniella Steel, Anders Lindahl, Björn Olsson, Peter Sartipy

Stem Cells

2008. Article. https://doi.org/10.1634/stemcells.2007-1033

Differentiating human embryonic stem cells express a unique housekeeping gene signature

Jane Synnergren, Therese L. Giesler, Sudeshna Adak, Reeti Tandon, Karin Noaksson, Anders Lindahl, Patric Nilsson, Deirdre Nelson, Björn Olsson, Mikael C. O. Englund, Stewart Abbott, Peter Sartipy

Stem Cells

2007. Article. https://doi.org/10.1634/stemcells.2006-0247

Differentiating human embryonic stem cells express a unique housekeeping gene signature

Jane Synnergren, Therese L Giesler, Adak Sudeshna, Reeti Tandon, Karin Noaksson, Anders Lindahl, Patric Nilsson, Deidre Nelson, Björn Olsson, Mikael C O Englund, Stewart Abbot, Peter Sartipy

4th ISSCR Annual Meeting

2006. Conference paper.

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BIO-AID - Biomedical AI-driven data analytics

Human stem cell based in vitro model of the blood brain barrier

Bioinformatics - Biomedical Big Data

Biomarkers for disease modelling

CardioTrophy - for reduced morbidity and mortality in cardiovascular diseases

AlgorOmics - developing new algorithms for biomarker identification

Biomarkers for toxicity testing

Aberrant DNA methylation patterns in hepatocytes derived from human pluripotent stem cells

Data-mining for Biomarker Discovery, Selection, and Validation

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