Institutionen för biovetenskap
Jane Synnergren is an Associate Professor at the University of Skövde, Sweden. She received her MSc in Computer Sciences from the University of Skövde in 2003 and started her graduate studies in bioinformatics in 2006. She recieved her PhD from University of Gothenburg in 2010. Her research interest is gene regulatory mechanisms that are important for stem cell differentiation. Working in close collaboration with the stem cell industry and the pharmaceutical industry she performs global expression studies of human pluripotent stem cells during their differentiation towards functional cell types, with a particular focus on heart-, liver- and neural cells. Results from her research have revealed gene expression patterns during the early phases of differentiation with potential importance for determining the fate of the stem cell. Results from recent studies have indicated important roles for miRNAs in the control of diverse aspects of heart formation and cardiac function. Her most recent research has been focused on identification of transcriptional biomarkers for toxic responses using hPSCs. She also performs research on epigenetic changes in hPSCs.
Current Perspectives on Multi-Omics Data Integration With Application on Toxicity Biomarkers DiscoverySynnergren Jane, Dönnes PierreOpen Access journal of Toxicology, 2018, 2(5), 1-2.
Expression profiling of human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin - integration and visualization of multi omics data
Holmgren Gustav, Sartipy Peter, Andersson Christian X. et al.Toxicological Sciences, 2018, 163(1), 182-195.
Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models
Lundin Anders, Delsing Louise, Clausen Maryam et al.Stem Cell Reports, 2018, 10(3), 1030-1045.
Integration of Biomedical Big Data Requires Efficient Batch Effect Reduction
Synnergren Jane, Ghosheh Nidal, Dönnes Pierre10th International Conference on Bioinformatics and Computational Biology (BICOB): Las Vegas, Nevada, USA 19 – 21 March 2018 (76-82). 2018.
A data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cellsUlfenborg Benjamin, Karlsson Alexander, Riveiro Maria et al.PLoS ONE, 2017, 12(6).
A novel maintenance medium extends the life-span and enables long term applications for both human primary hepatocytes and human pluripotent stem cell derived hepatocytes in conventional 2D cultures
Asplund Annika, Synnergren Jane, Andersson Christian X. et al.14th European ISSX Meeting, Cologne, Germany, June 26-29, 2017. International Society for the Study of Xenobiotics, 2017.
Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue
Ghosheh Nidal, Küppers-Munther Barbara, Asplund Annika et al.Physiological Genomics, 2017, 49(8), 430-446.
CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients
Skillbäck Tobias, Delsing Louise, Synnergren Jane et al.Neurobiology of Aging, 2017, 59, 1-9.
Human iPSC-derived endothelial cells can develop in to brain-like endothelial cells after coculture with primary human brain cells
Delsing Louise, Synnergren Jane, Hicks Ryan et al.International Symposium for Stem Cell Research, Boston, June 14-17, 2017 (523). International Society for Stem Cell Research, 2017.
Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days
Starokozhko Viktoriia, Vatakuti Suresh, Schievink Bauke H. et al.Archives of Toxicology, 2017, 91(5), 2079-2092.