Institutionen för biovetenskap
Jane Synnergren is an Associate Professor at the University of Skövde, Sweden. She received her MSc in Computer Sciences from the University of Skövde in 2003 and started her graduate studies in bioinformatics in 2006. She recieved her PhD from University of Gothenburg in 2010. Her research interest is gene regulatory mechanisms that are important for stem cell differentiation. Working in close collaboration with the stem cell industry and the pharmaceutical industri she performs global expression studies of human pluripotent stem cells during their differentiation towards functional cell types, with a particular focus on heart-, liver- and neural cells. Results from her research have revealed gene expression patterns during the early phases of differentiation with potential importance for determining the fate of the stem cell. Results from recent studies have indicated important roles for miRNAs in the control of diverse aspects of heart formation and cardiac function. Her most recent research has been focused on identification of transcriptional biomarkers for toxic responses using hPSCs. She also performs research on epigenetic changes in hPSCs.
A data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cellsUlfenborg Benjamin, Karlsson Alexander, Riveiro Maria et al.PLoS ONE, 2017, 12(6).
Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue
Ghosheh Nidal, Küppers-Munther Barbara, Asplund Annika et al.Physiological Genomics, 2017, 49(8), 430-446.
CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients
Skillbäck Tobias, Delsing Louise, Synnergren Jane et al.Neurobiology of Aging, 2017, 59, 1-9.
Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days
Starokozhko Viktoriia, Vatakuti Suresh, Schievink Bauke H. et al.Archives of Toxicology, 2017, 91(5), 2079-2092.
Comparative transcriptomic analysis identifies genes differentially expressed in human epicardial progenitors and hiPSC-derived cardiac progenitorsSynnergren Jane, Drowley Lauren, Plowright Alleyn T. et al.Physiological Genomics, 2016, 48(11), 771-784.
Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines
Ghosheh Nidal, Olsson Björn, Edsbagge Josefina et al.Stem Cells International, 2016, 2016.
Interactive visualization of large-scale gene expression data
Riveiro Maria, Lebram Mikael, Andersson Christian X. et al.Information Visualisation: Computer Graphics, Imaging and Visualisation (348-354). IEEE Computer Society, 2016.
MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity
Holmgren Gustav, Synnergren Jane, Andersson Christian X. et al.Toxicology in Vitro, 2016, 34, 26-34.
Towards Creating the Perfect In Vitro Cell Model
Jonsson Malin K. B., van Veen Toon A. B., Synnergren Jane et al.Stem Cells International, 2016, 2016.
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cellsGodoy Patricio, Schmidt-Heck Wolfgang, Natarajan Karthick et al.Journal of Hepatology, 2015, 63(4), 934-942.