Institutionen för biovetenskap
Jane Synnergren is an Associate Professor at the University of Skövde, Sweden. She received her MSc in Computer Sciences from the University of Skövde in 2003 and started her graduate studies in bioinformatics in 2006. She recieved her PhD from University of Gothenburg in 2010. Her research interest is gene regulatory mechanisms that are important for stem cell differentiation. Working in close collaboration with the stem cell industry and the pharmaceutical industri she performs global expression studies of human pluripotent stem cells during their differentiation towards functional cell types, with a particular focus on heart-, liver- and neural cells. Results from her research have revealed gene expression patterns during the early phases of differentiation with potential importance for determining the fate of the stem cell. Results from recent studies have indicated important roles for miRNAs in the control of diverse aspects of heart formation and cardiac function. Her most recent research has been focused on identification of transcriptional biomarkers for toxic responses using hPSCs. She also performs research on epigenetic changes in hPSCs.
Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cellsHolmgren Gustav, Synnergren Jane, Bogestål Yalda et al.Toxicology, 2015, 328, 102-111.
Identification of stable reference genes in differentiating human pluripotent stem cells
Holmgren Gustav, Ghosheh Nidal, Zeng Xianmin et al.Physiological Genomics, 2015, 47(6), 232-239.
Clinical Outcome 3 Years After Autologous Chondrocyte Implantation Does Not Correlate With the Expression of a Predefined Gene Marker Set in Chondrocytes Prior to Implantation but Is Associated With Critical Signaling PathwaysStenberg Johan, de Windt Tommy S., Synnergren Jane et al.Orthopaedic journal of sports medicine, 2014, 2(9), 1-14.
Effects of interleukin-6 and interleukin-1β on expression of growth differentiation factor-5 and Wnt signaling pathway genes in equine chondrocytes
Svala Emilia, Thorfve Anna I., Ley Cecilia et al.American Journal of Veterinary Research, 2014, 75(2), 132-140.
Explore transcription factor profiles in human pluripotent stem cells
Synnergren Jane6th International Conference on Bioinformatics and Computational Biology (BICoB 2014): Las Vegas, Nevada, USA, 24 – 26 March 2014 (197-202). International Society for Computers and Their Applications, 2014.
Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes
Holmgren Gustav, Sjögren Anna-Karin, Barragan Isabel et al.Drug Metabolism And Disposition, 2014, 42(9), 1401-1406.
Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactorSivertsson Louise, Synnergren Jane, Jensen Janne et al.Stem Cells and Development, 2013, 22(4), 581-594.
Identification of miRNAs in Control of Aberrant Gene Transcription in Human Pluripotent Stem Cell Derived Hepatocytes
Synnergren JaneComputer Applications in Industry and Engineering (CAINE-2013), 26th International Conference September 25-27, 2013, Los Angeles, California, USA (11-16). International Society for Computers and Their Applications, 2013.
Comparison of human cardiac gene expression profiles in paired samples of right atrium and left ventricle collected in vivoAsp Julia, Synnergren Jane, Jonsson Marianne et al.Physiological Genomics, 2012, 44(1), 89-98.
Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue
Synnergren Jane, Ameen Caroline, Jansson Andreas et al.Physiological Genomics, 2012, 44(4), 245-258.