Institutionen för biovetenskap
I am Associate Professor in bioinformatics at the University of Skövde, Sweden, and Head of the Translational Bioinformatics research group consisting of a group of 19 researchers with a dedicated interest in bioinformatics. I have a background in Data Science and received my MSc in Computer Sciences from the University of Skövde in 2003. During my graduate studies I developed my expertise in bioinformatics and large-scale omics data analysis and received my PhD from the University of Gothenburg in 2010.
My research is focused on analysis methods for identification of biomarkers and integration of multiple types of omics data. I am PI for several research projects specialized in stem cell differentiation, toxicity testing and disease modeling using stem cell based in vitro systems. I am also leading projects particularly focused on advanced analysis of big data, biomarker identification, and data integration with particular interest in machine-learning methods.
Working in close collaboration with the stem cell industry and the pharmaceutical industry we perform global expression studies including transcriptomics, proteomics, epigenomics, and metabolomics of human pluripotent stem cells during their differentiation towards functional cell types. The results from these studies have revealed mechanistic highlights during the early phases of stem cell differentiation and identified biomarkers with potential importance for applications in toxicity testing, drug development, and disease modeling.
A novel maintenance medium extends the life-span and enables long term applications for both human primary hepatocytes and human pluripotent stem cell derived hepatocytes in conventional 2D culturesAsplund Annika, Synnergren Jane, Andersson Christian X. et al.14th European ISSX Meeting, Cologne, Germany, June 26-29, 2017. International Society for the Study of Xenobiotics, 2017.
Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue
Ghosheh Nidal, Küppers-Munther Barbara, Asplund Annika et al.Physiological Genomics, 2017, 49(8), 430-446.
CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients
Skillbäck Tobias, Delsing Louise, Synnergren Jane et al.Neurobiology of Aging, 2017, 59, 1-9.
Human iPSC-derived endothelial cells can develop in to brain-like endothelial cells after coculture with primary human brain cells
Delsing Louise, Synnergren Jane, Hicks Ryan et al.International Symposium for Stem Cell Research, Boston, June 14-17, 2017 (523). International Society for Stem Cell Research, 2017.
Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days
Starokozhko Viktoriia, Vatakuti Suresh, Schievink Bauke H. et al.Archives of Toxicology, 2017, 91(5), 2079-2092.
Visual integration of multiple omics data from human pluripotent stem cell-derived cardiomyocytes
Sartipy Peter, Holmgren Gustav, Synnergren Jane et al.International Society for Stem Cell Research (ISSCR) Annual meeting, Boston 14–17 June 2017 (13). 2017.
Comparative transcriptomic analysis identifies genes differentially expressed in human epicardial progenitors and hiPSC-derived cardiac progenitorsSynnergren Jane, Drowley Lauren, Plowright Alleyn T. et al.Physiological Genomics, 2016, 48(11), 771-784.
Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines
Ghosheh Nidal, Olsson Björn, Edsbagge Josefina et al.Stem Cells International, 2016, 2016.
Interactive visualization of large-scale gene expression data
Riveiro Maria, Lebram Mikael, Andersson Christian X. et al.Information Visualisation: Computer Graphics, Imaging and Visualisation (348-354). IEEE Computer Society, 2016.
MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity
Holmgren Gustav, Synnergren Jane, Andersson Christian X. et al.Toxicology in Vitro, 2016, 34, 26-34.