Institutionen för biovetenskap
Jane Synnergren is an Associate Professor at the University of Skövde, Sweden. She received her MSc in Computer Sciences from the University of Skövde in 2003 and started her graduate studies in bioinformatics in 2006. She recieved her PhD from University of Gothenburg in 2010. Her research interest is gene regulatory mechanisms that are important for stem cell differentiation. Working in close collaboration with the stem cell industry and the pharmaceutical industry she performs global expression studies of human pluripotent stem cells during their differentiation towards functional cell types, with a particular focus on heart-, liver- and neural cells. Results from her research have revealed gene expression patterns during the early phases of differentiation with potential importance for determining the fate of the stem cell. Results from recent studies have indicated important roles for miRNAs in the control of diverse aspects of heart formation and cardiac function. Her most recent research has been focused on identification of transcriptional biomarkers for toxic responses using hPSCs. She also performs research on epigenetic changes in hPSCs.
Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell LinesGhosheh Nidal, Olsson Björn, Edsbagge Josefina et al.Stem Cells International, 2016, 2016.
Interactive visualization of large-scale gene expression data
Riveiro Maria, Lebram Mikael, Andersson Christian X. et al.Information Visualisation: Computer Graphics, Imaging and Visualisation (348-354). IEEE Computer Society, 2016.
MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity
Holmgren Gustav, Synnergren Jane, Andersson Christian X. et al.Toxicology in Vitro, 2016, 34, 26-34.
Towards Creating the Perfect In Vitro Cell Model
Jonsson Malin K. B., van Veen Toon A. B., Synnergren Jane et al.Stem Cells International, 2016, 2016.
Transcriptional profiling of human embryonic stem cells during mesodermal- and cardiac differentiation
Synnergren Jane Marie, Ameén Caroline, Åkesson Karolina et al.International Society for Stem Cell Research (ISSCR) Annual meeting, San Fransisco 22–25 June 2016 (432). International Society for Stem Cell Research, 2016.
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cellsGodoy Patricio, Schmidt-Heck Wolfgang, Natarajan Karthick et al.Journal of Hepatology, 2015, 63(4), 934-942.
Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells
Holmgren Gustav, Synnergren Jane, Bogestål Yalda et al.Toxicology, 2015, 328, 102-111.
Identification of stable reference genes in differentiating human pluripotent stem cells
Holmgren Gustav, Ghosheh Nidal, Zeng Xianmin et al.Physiological Genomics, 2015, 47(6), 232-239.
Clinical Outcome 3 Years After Autologous Chondrocyte Implantation Does Not Correlate With the Expression of a Predefined Gene Marker Set in Chondrocytes Prior to Implantation but Is Associated With Critical Signaling PathwaysStenberg Johan, de Windt Tommy S., Synnergren Jane et al.Orthopaedic journal of sports medicine, 2014, 2(9), 1-14.
Effects of interleukin-6 and interleukin-1β on expression of growth differentiation factor-5 and Wnt signaling pathway genes in equine chondrocytes
Svala Emilia, Thorfve Anna I., Ley Cecilia et al.American Journal of Veterinary Research, 2014, 75(2), 132-140.