Institutionen för biovetenskap
Jane Synnergren is an Associate Professor at the University of Skövde, Sweden. She received her MSc in Computer Sciences from the University of Skövde in 2003 and started her graduate studies in bioinformatics in 2006. She recieved her PhD from University of Gothenburg in 2010. Her research interest is gene regulatory mechanisms that are important for stem cell differentiation. Working in close collaboration with the stem cell industry and the pharmaceutical industri she performs global expression studies of human pluripotent stem cells during their differentiation towards functional cell types, with a particular focus on heart-, liver- and neural cells. Results from her research have revealed gene expression patterns during the early phases of differentiation with potential importance for determining the fate of the stem cell. Results from recent studies have indicated important roles for miRNAs in the control of diverse aspects of heart formation and cardiac function. Her most recent research has been focused on identification of transcriptional biomarkers for toxic responses using hPSCs. She also performs research on epigenetic changes in hPSCs.
High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart tissueMagnusson Lisa U., Lundqvist Annika, Asp Julia et al.Biochemical and Biophysical Research Communications - BBRC, 2012, 424(2), 327-330.
MicroRNA regulatory network involved in impaired functionality in cardiomyocytes derived from human embryonic stem cells
Synnergren Jane25th International Conference on Computer Applications in Industry and Engineering 2012 (CAINE-2012) Held with the 4th International Symposium on Sensor Network and Application (SNA-2012): New Orleans, Louisiana, USA 14-16 November 2012 (133-138). International Society for Computers and Their Applications, 2012.
Transcriptional analysis of messenger-RNA and micro-RNA array data reveals global negative correlation in human stem cell derived cardiomyocyte clusters
Synnergren Jane, Sartipy Peter4th International Conference on Bioinformatics and Computational Biology (178-183). Curran Associates, Inc., 2012.
Expression of microRNAs and their target mRNAs in human stem cell-derived cardiomyocyte clusters and in heart tissueSynnergren Jane, Améen Caroline, Lindahl Anders et al.Physiological Genomics, 2011, 43(10), 581-594.
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
Yildirimman Reha, Brolén Gabriella, Vilardell Mireia et al.Toxicological Sciences, 2011, 124(2), 278-290.
Microarray Analysis of Undifferentiated and Differentiated Human Pluripotent Stem Cells
Synnergren Jane, Sartipy PeterMethodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications (343-366). Rijeka, Croatia: INTECH, 2011.
Clustering micro-RNA array data using an information fusion based approach with multiple types of input dataSynnergren Jane, Özdogan Alper, Olsson Björn et al.Proceedings of the ISCA 2nd International Conference on Bioinformatics and Computational Biology, BICoB-2010, March 24-26, 2010, Sheraton Waikiki Hotel, Honolulu, Hawaii, USA (151-158). International Society for Computers and Their Applications, 2010.
Human Embryonic Mesodermal Progenitors Highly Resemble Human Mesenchymal Stem Cells and Display High Potential for Tissue Engineering Applications
de Peppo G.M., Svensson S., Lennerås M. et al.Tissue Engineering. Part A, 2010, 16(7), 2161-2182.
Transcriptional profiling of human embryonic stem cells and their functional derivatives
Synnergren JaneDoktorsavhandling: Göteborgs universitet, 2010.
Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further towards the hepatic lineage
Synnergren Jane, Heins Nico, Brolén Gabriella et al.Stem Cells and Development, 2010, 19(7), 961-978.