Jane Synnergren work as a postdoc at the University of Skövde, Sweden. She received her MSc in Computer Sciences from the University of Skövde in 2003 and started her graduate studies in bioinformatics in 2006 and graduated in 2010. Her research interest is gene regulatory mechanisms that are important for stem cell differentiation. Working in close collaboration with the stem cell industry, she performs global gene expression studies of human embryonic stem cells during their differentiation towards functional cell types, with a particular focus on heart- and liver-cells. Results from her research have revealed gene expression patterns during the early phases of differentiation with potential importance for determining the fate of the stem cell. Results from recent studies have indicated important roles for miRNAs in the control of diverse aspects of heart formation and cardiac function. Her most recent research has been focused on miRNA expression during cardiac differentiation.
Publications:
Peer reviewed scientific journal papers
Synnergren, J., Giesler, T.L., Adak, S., Tandon, R., Noaksson, K., Lindahl, A. Nilsson, P., Nelson, D., Olsson, B., Englund, M.C.O., Abbot, S., Sartipy, P. (2007) Differentiating human embryonic stem cells express a unique housekeeping gene signature. Stem Cells, 25(2): 473-480.
Synnergren J., Adak S., Englund M.C., Giesler T.L., Noaksson K., Lindahl A., Nilsson P., Nelson D., Abbot S., Olsson B., and Sartipy P. (2008) Cardiomyogenic gene expression profiling of differentiating human embryonic stem cells. J Biotechnol. 134: 162-170.
Synnergren J., Åkesson K., Dahlenborg K., Vidarsson H., Améen C., Steel D., Lindahl A., Olsson B., and Sartipy P. (2008) Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells. Stem Cells, 26(7): 1831-1840.
Synnergren J., Olsson B., Gamalielsson J. (2009) Classification of Information Fusion Methods in System Biology. In Silico Biology, 9: 1-12.
Sartipy P., Olsson B., Hyllner J., Synnergren J. (2009) Regulation of 'Stemness' and Stem Cell Differentiation by MicroRNAs. IDrugs, Aug;12(8): 492-496.
Synnergren J., Heins N, Brolén G, Eriksson G, Lindahl A, Hyllner J, Olsson B, Sartipy P, Björquist P. (2010) Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further towards the hepatic lineage. Stem Cells Dev. 19(7): 961-978.
de Peppo G.M., Svensson S., Lennerås M., Synnergren J., Stenberg J., Strehl R., Hyllner J., Thomsen P., Karlsson C. (2010) Human Embryonic Mesodermal Progenitors Highly Resemble Human Mesenchymal Stem Cells and Display High Potential for Tissue Engineering Applications. Tissue Eng. Part A, 16(7): 2161-2182.
Synnergren J., Améen C., Lindahl A., Olsson B., and Sartipy P. (2011) Expression of microRNAs and their target mRNAs in human stem cell derived cardiomyocyte clusters and in heart tissue. Accepted for publication in Physiol Genomics, 43(10):581-94.
Yildirimman R., Brolén G., Vilardell M., Eriksson G., Synnergren J., Gmuender H., Kamburov A., Ingelman-Sundberg M., Castell J., Lahoz A., Kleinjans J., van Delft J., Björquist P., Herwig R. Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicological Sciences, in press.
Peer reviewed conference papers
Synnergren J., Gamalielsson J., and Olsson B. (2007), Mapping of the JDL Data Fusion Model to Bioinformatics, In Proc. the 2007 IEEE International Conference on Systems, Man and Cybernetics (SMC 2007), page 1506-1511, 7-10 Oct, Montreal, Canada. ISBN: 978-1-4244-0991-4.
Synnergren J., Olsson B., Gamalielsson J. (2008) A Data Integration Method for Exploring Gene Regulatory Mechanisms. Conference on Intergration and Knowledge Management (CIKM), 26-30 Oct 2008, Napa Valley, California, USA.
Synnergren J., Özdogan A., Olsson B., and Sartipy P. (2010) Clustering micro-RNA array data using an information fusion based approach with multiple types of input data. Second International Conference on Bioinformatics and Computational Biology (BiCoB), 24-26 March 2010, Honolulu, Hawaii, USA.
Book chapters
Synnergren J. and Sartipy P. Microarray Analysis of Undifferentiated and Differentiated Human Pluripotent Stem Cells. In: Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications. ISBN 978-953-307-197-8, Edited by: Craig Atwood, InTech. April 2011.
Patent and patent applications
Patent Application Title: “Cardiomyocyte-like cell clusters derived from hBS cells”. Filed 2007, Inventors: Peter Sartipy, Karolina Åkesson, Caroline Améen, Kerstin Dahlenborg, Jane Synnergren, and Daniella Steel. Exploited by Cellartis AB.
Patent Application Title: “Novel microRNAs for the detection and isolation of human embryonic stem cell- derived cardiac cell types.” Filed 2010, Inventors: Peter Sartipy and Jane Synnergren. Exploited by Cellartis AB.
Thesis
Synnergren, J. (2003). Wheat variety identification using genetic variations, HS-IDA-MD-03-007, MSc-thesis, University of Skövde, Sweden, June 2003.
Synnergren, J. (2010). Transcriptional profiling of human embryonic stem cells and their functional derivatives. ISBN 978-91-628-8169-6.
Technical reports
Synnergren, J. (2006). Understanding the differentiation of human embryonic stem cells, HS-IKI-TR-06-003, Technical report, University of Skövde, Sweden, April 2006.