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      University of Skövde, link to startpage

      Helene Lindholm

      PhD Student Biomedicine
      School of Health Sciences
      Room G2304

      Research

      2023

      Linda Handlin, Giovanni Novembre, Heléne Lindholm, Robin Kämpe, Elisabeth Paul, India Morrison

      2022

      2020

      Heléne Lindholm, India Morrison, Alexandra Krettek, Dan Malm, Giovanni Novembre, Linda Handlin

      BMC Medical Genetics

      2020. Article. https://doi.org/10.1186/s12881-020-01123-w Open Access

      2001

      Åsa Sjöling, Heléne Lindholm, E. Samuelson, Y. Yamasaki, T. K. Watanabe, A. Tanigami, G. Levan

      Cytogenetics and Cell Genetics

      2001. Article. https://doi.org/10.1159/000059347

      Ongoing projects

      Evaluation of new pharmaceutical compounds and their effects in the area of cancer and also in stroke

      Enzymatic inhibitors that slow down the production of ROS (reactive oxygen species) have been shown to be effective in mitigating the effects of a stroke. Additional effects, such as reduced growth of cancer cells have also been detected. This area of research is very exciting as no approved drugs with similar effects are available today.

      January 2016 - December 2025 DHEAR – for a healthier and more sustainable soci

      Food – Gut – Brain – Mind – Health

      The study is a human study for healthy volunteers who for three weeks replace their usual diet with a ketogenic diet. Metabolic, microbiotic, neurobiological and clinical parameters are measured before and after the study. This means that a whole-body perspective is taken into account when it comes to health, but also the mental part as well as how the mentally status linked to the dietary change.

      September 2020 - December 2025 DHEAR

      Finished projects

      NOX, ROS and metabolism in Pancreatic Ductal Adenocarcinoma

      The scientific work that will be performed in this project is to explore new pathways of cancer treatment with particular focus on pancreatic cancer. These new ways of treatment are based on changing the functions of different signaling and metabolic pathways such as NADPH oxidase (NOX), reactive oxygen species (ROS) and metabolism which are known to be up-regulated or malfunctioning in cancer cells. By using different chemicals such as NOX inhibitors, digitoxin and ketone bodies inhibit their activity and thereby decrease the cell viability of the cancer cells. Focusing treatment on the differences between normal / cancer cells would help develop methods that inhibit cancer cells with less negative effects on normal cells.

      September 2016 - September 2021 DHEAR
      Published: 1/9/2020
      Edited: 1/9/2020
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