Diana Tilevik
Head of Division/Senior Lecturer in Systems Biology
School of Bioscience
Room G3307
My research mainly focuses on the use of mathematical, computational and statistical methods and models in the area of infection biology. In recent years, my research has been directed more towards translational medicine, especially in development and application of data-mining methods on large-scale biomarker data. Although that the advent of high-throughput technologies capable of producing large-scale biological data has provided an excellent opportunity for the discovery of novel biomarkers, it has simultaneously complicated the problem of mining meaningful biomarker signatures as analysis and interpretation of such complex data require sophisticated systems biology approaches.
My ongoing research aims at developing accurate and transparent diagnosis support systems for early identification of patients with bacterial sepsis, and includes the projects Data-mining for biomarker discovery, selection, and validation (2017-2021, Knowledge Foundation), Next generation sepsis diagnosis (2016-2021, EU, H2020), Development of sepsis diagnosis system (2016-2019, Knowledge Foundation), and Microbial diversity in patients suspected with sepsis (financed through several research grants). Current research collaborators include Skaraborg Hospital, Unilabs AB, TATAA Biocenter AB, Gothenburg University, bioMérieux Sweden AB, 1928Diagnostics AB, Olink Proteomics AB, QIAGEN AB, Danska Tekniska Universitetet, Copenhagen Business School, Charles University, Danube University, Deutsches Institut fur Normung, CubeDx, and Zoetis.
I gained my master degree in Molecular Computational Biology from University of Skövde in 2004, and I defended my PhD, entitled “Studies on emergence and spread of antibiotic resistant Streptococcus pneumoniae”, at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet in 2010. Currently, I´m a Senior Lecturer in Systems Biology, Head of Systems Biology, a member of the Infection Biology Group and the Systems Biology Research Centre at the University of Skövde.
Research
Publications
Projects
2023
BMC Infectious Diseases
2023. Article.
https://doi.org/10.1186/s12879-022-07977-0
2022
Microbial Pathogenesis
2022. Article.
https://doi.org/10.1016/j.micpath.2022.105836
2021
Frontiers in Microbiology
2021. Article.
https://doi.org/10.3389/fmicb.2021.640408
2019
Evaluation of QuickFISH and maldi Sepsityper for identification of bacteria in bloodstream infection
Infectious Diseases
2019. Article.
https://doi.org/10.1080/23744235.2018.1554258
14th Annual Workshop in Systems Biology, University of Skövde, Sweden, 21 November 2019
2019. Conference paper, poster.
14th Annual Workshop in Systems Biology, University of Skövde, Sweden, 21 November 2019
2019. Conference paper, poster.
29th European Congress of Clinical Microbiology and Infectious Diseases, ECCMID, Amsterdam, Netherlands, 13-16 April, 2019
2019. Conference paper, poster.
29th European Congress of Clinical Microbiology and Infectious Diseases, ECCMID, Amsterdam, Netherlands, 13-16 April, 2019
2019. Conference paper, poster.
2018
Laboratory Investigation
2018. Article, review. https://doi.org/10.1038/s41374-018-0143-3
2017
Digital Human Modeling - Applications in Health, Safety, Ergonomics, and Risk Management: Health and Safety: 8th International Conference, DHM 2017 Held as Part of HCI International 2017 Vancouver, BC, Canada, July 9–14, 2017, Proceedings, Part II
2017. Conference paper. https://doi.org/10.1007/978-3-319-58466-9_3