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      miRSeps - Future diagnostics of sepsis

      Research Group Infection Biology
      Resarch Environment Systems Biology

      miRSeps - Future diagnostics of sepsis

      Research Group Infection Biology
      Resarch Environment Systems Biology

      Quick Facts

      Full project name

      Future diagnostics of sepsis - miRSeps

      Duration

      January 2020 – December 2022

      Partners

      TATAA Biocenter AB, Unilabs AB, QIAGEN AB, Public healthcare Skaraborg Hospital, Swedish Institute for Standards.

      Financing

      Knowledge Foundation

      This project is one of several ongoing projects in the research "Future diagnostics of sepsis". The goal is to develop earlier and more accurate diagnostics for sepsis in order to increase the chance of patients suffering from survival and with less disease complications.

      Sepsis arises when the body's response to an infection damages its own tissues and organs. It can lead to shock, multiple organ failures and death, especially if it is not recognized early and treated promptly.

      Nonspecific symtoms

      As the symptoms for sepsis are nonspecific and similar to other conditions, it remains challenging for the physicians to identify the sepsis patients, especially at an early stage. As time to diagnosis and initiation of adequate antimicrobial therapy are critical parameters for the outcome of a septic patient, there is an urgent need for new approaches for sepsis diagnostics.

      Current biomarkers cannot identify sepsis

      Current biomarkers used in sepsis diagnostics cannot accurately identify patients with sepsis. Besides, since sepsis gives rise to a complex host immune response, it appears unlikely that a single biomarker adequately can describe stratify the sepsis syndrome.

      We have previously identified tentative multimarker panels with potential of differentiating between septic patients with bacterial cause and those with non-bacterial cause. The multimarker panels consist of a number of microRNAs in combination with clinical routine biomarkers.

      25 unique microRNAs

      In total, 25 unique microRNAs and three clinical routine biomarkers have been identified previously providing input data to eight candidate models. In the current project, we are going to validate these eight candidate models, miRSeps™. Furthermore, end-user guidelines for the interpretation of the output from miRSeps™ will also be established.

      Project in media

      More information about Sepsis 

       

      Project leader

      Avd.chef/Lektor systembiologi

      Participating Researchers

      Partners and financing

      Knowledge Foundation
      TATAA Biocenter AB
      Unilabs
      Västra Götaland Region