Jane Synnergren

Data Mining Identifies CCN2 and THBS1 as Biomarker Candidates for Cardiac Hypertrophy

Markus Johansson, Benyapa Tangruksa, Sepideh Heydarkhan-Hagvall, Anders Jeppsson, Peter Sartipy, Jane Synnergren

Life

2022. Artikel. https://doi.org/10.3390/life12050726 Open Access

Multi-Omics Characterization of a Human Stem Cell-Based Model of Cardiac Hypertrophy

Markus Johansson, Benjamin Ulfenborg, Christian X. Andersson, Sepideh Heydarkhan-Hagvall, Anders Jeppsson, Peter Sartipy, Jane Synnergren

Life

2022. Artikel. https://doi.org/10.3390/life12020293 Open Access

Human intracardiac SSEA4+CD34 cells show features of cycling, immature cardiomyocytes and are distinct from Side Population and C-kit+CD45- cells

Mikael Sandstedt, Kristina Vukusic, Benjamin Ulfenborg, Marianne Jonsson, Lillemor Mattsson Hultén, Göran Dellgren, Anders Jeppsson, Jane Synnergren, Joakim Sandstedt

PLOS ONE

2022. Artikel. https://doi.org/10.1371/journal.pone.0269985 Open Access

Multimodal deep learning for biomedical data fusion: a review

Sören Richard Stahlschmidt, Benjamin Ulfenborg, Jane Synnergren

Briefings in Bioinformatics

2022. Artikel, forskningsöversikt. https://doi.org/10.1093/bib/bbab569 Open Access

Unraveling the Metabolic Derangements Occurring in Non-infarcted Areas of Pig Hearts With Chronic Heart Failure

Cláudia Correia, Qing-Dong Wang, Gunilla Linhardt, Leif G. Carlsson, Benjamin Ulfenborg, Anna Walentinsson, Katarina Rydén-Markinhutha, Margareta Behrendt, Johannes Wikström, Peter Sartipy, Karin Jennbacken, Jane Synnergren

Frontiers in Cardiovascular Medicine

2021. Artikel. https://doi.org/10.3389/fcvm.2021.753470 Open Access

Multi-Assignment Clustering: Machine learning from a biological perspective

Benjamin Ulfenborg, Alexander Karlsson, Maria Riveiro, Christian X. Andersson, Peter Sartipy, Jane Synnergren

Journal of Biotechnology

2021. Artikel. https://doi.org/10.1016/j.jbiotec.2020.12.002 Open Access

Models of the blood-brain barrier using iPSC-derived cells

Louise Delsing, Anna Herland, Anna Falk, Ryan Hicks, Jane Synnergren, Henrik Zetterberg

Molecular and Cellular Neuroscience

2020. Artikel. https://doi.org/10.1016/j.mcn.2020.103533 Open Access

Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver Tissue

Nidal Ghosheh, Barbara Küppers-Munther, Annika Asplund, Christian X. Andersson, Petter Björquist, Tommy B. Andersson, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren

ACS Omega

2020. Artikel. https://doi.org/10.1021/acsomega.9b03514 Open Access

Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases

Gustav Holmgren, Benjamin Ulfenborg, Annika Asplund, Karin Toet, Christian X. Andersson, Ann Hammarstedt, Roeland Hanemaaijer, Barbara Küppers-Munther, Jane Synnergren

International Journal of Molecular Sciences

2020. Artikel. https://doi.org/10.3390/ijms21020469 Open Access

Cardiac hypertrophy in a dish: a human stem cell based model

Markus Johansson, Benjamin Ulfenborg, Christian X. Andersson, Sepideh Heydarkhan-Hagvall, Anders Jeppsson, Peter Sartipy, Jane Synnergren

Biology open

2020. Artikel. https://doi.org/10.1242/bio.052381 Open Access

Transcriptional sex and regional differences in paired human atrial and ventricular cardiac biopsies collected in vivo

Jane Synnergren, Kristina Vukusic, Pierre Dönnes, Marianne Jonsson, Anders Lindahl, Göran Dellgren, Anders Jeppsson, Julia Asp

Physiological Genomics

2020. Artikel. https://doi.org/10.1152/physiolgenomics.00036.2019

Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood-brain barrier model

Louise Delsing, Therese Kallur, Henrik Zetterberg, Ryan Hicks, Jane Synnergren

Fluids and Barriers of the CNS

2019. Artikel. https://doi.org/10.1186/s12987-019-0147-4 Open Access

Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models

Cecilia Granéli, Ryan Hicks, Gabriella Brolén, Jane Synnergren, Peter Sartipy

Stem Cell Reviews

2019. Artikel. https://doi.org/10.1007/s12015-018-9858-1 Open Access

Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier

Louise Delsing, Pierre Dönnes, José Sánchez, Maryam Clausen, Dmitrios Voulgaris, Anna Falk, Anna Herland, Gabriella Brolén, Henrik Zetterberg, Ryan Hicks, Jane Synnergren

Stem Cells

2018. Artikel. https://doi.org/10.1002/stem.2908 Open Access

Expression profiling of human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin - integration and visualization of multi omics data

Gustav Holmgren, Peter Sartipy, Christian X. Andersson, Anders Lindahl, Jane Synnergren

Toxicological Sciences

2018. Artikel. https://doi.org/10.1093/toxsci/kfy012

Novel human iPSC-derived hepatocytes with advanced functionality and long-term 2D cultures of human primary hepatocytes for metabolic disease studies

Barbara Küppers-Munther, A. Asplund, Benjamin Ulfenborg, Jane Synnergren, A. Abadie

Human Gene Therapy

2018. Artikel, meeting abstract. https://doi.org/10.1089/hum.2018.29077.abstracts

Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models

Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, José Sanchez, Alan Sabirsh, Mei Ding, Jane Synnergren, Henrik Zetterberg, Gabriella Brolén, Ryan Hicks, Anna Herland, Anna Falk

Stem Cell Reports

2018. Artikel. https://doi.org/10.1016/j.stemcr.2018.01.021 Open Access

Current Perspectives on Multi-Omics Data Integration With Application on Toxicity Biomarkers Discovery

Jane Synnergren, Pierre Dönnes

Open Access journal of Toxicology

2018. Artikel, forskningsöversikt. https://doi.org/10.19080/OAJT.2018.02.555597 Open Access

Integration of Biomedical Big Data Requires Efficient Batch Effect Reduction

Jane Synnergren, Nidal Ghosheh, Pierre Dönnes

10th International Conference on Bioinformatics and Computational Biology (BICOB): Las Vegas, Nevada, USA 19 – 21 March 2018

2018. Konferensbidrag.

A novel maintenance medium extends the life-span and enables long term applications for both human primary hepatocytes and human pluripotent stem cell derived hepatocytes in conventional 2D cultures

Annika Asplund, Jane Synnergren, Christian X. Andersson, Barbara Küppers-Munther

14th European ISSX Meeting, Cologne, Germany, June 26-29, 2017

2017. Konferensbidrag, poster.

Human iPSC-derived endothelial cells can develop in to brain-like endothelial cells after coculture with primary human brain cells

Louise Delsing, Jane Synnergren, Ryan Hicks, Henrik Zetterberg

International Symposium for Stem Cell Research, Boston, June 14-17, 2017

2017. Konferensbidrag, poster.

Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue

Nidal Ghosheh, Barbara Küppers-Munther, Annika Asplund, Josefina Edsbagge, Benjamin Ulfenborg, Tommy B. Andersson, Petter Björquist, Christian X. Andersson, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren

Physiological Genomics

2017. Artikel. https://doi.org/10.1152/physiolgenomics.00007.2017 Open Access

Visual integration of multiple omics data from human pluripotent stem cell-derived cardiomyocytes

Peter Sartipy, Gustav Holmgren, Jane Synnergren, Christian Andersson, Anders Lindahl

International Society for Stem Cell Research (ISSCR) Annual meeting, Boston 14–17 June 2017

2017. Konferensbidrag, poster.

CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients

Tobias Skillbäck, Louise Delsing, Jane Synnergren, Niklas Mattsson, Shorena Janelidze, Katarina Nägga, Lena Kilander, Ryan Hicks, Anders Wimo, Bengt Winblad, Oskar Hansson, Kaj Blennow, Maria Eriksdotter, Henrik Zetterberg

Neurobiology of Aging

2017. Artikel. https://doi.org/10.1016/j.neurobiolaging.2017.06.028

Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days

Viktoriia Starokozhko, Suresh Vatakuti, Bauke H. Schievink, Marjolijn T. Merema, Annika Asplund, Jane Synnergren, Anders Aspegren, Geny M. M. Groothuis

Archives of Toxicology

2017. Artikel. https://doi.org/10.1007/s00204-016-1865-x Open Access

A data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells

Benjamin Ulfenborg, Alexander Karlsson, Maria Riveiro, Caroline Améen, Karolina Åkesson, Christian X. Andersson, Peter Sartipy, Jane Synnergren

PLOS ONE

2017. Artikel. https://doi.org/10.1371/journal.pone.0179613 Open Access

Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines

Nidal Ghosheh, Björn Olsson, Josefina Edsbagge, Barbara Küppers-Munther, Mariska Van Giezen, Annika Asplund, Tommy B. Andersson, Petter Björquist, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren

Stem Cells International

2016. Artikel. https://doi.org/10.1155/2016/8648356 Open Access

MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity

Gustav Holmgren, Jane Synnergren, Christian X. Andersson, Anders Lindahl, Peter Sartipy

Toxicology in Vitro

2016. Artikel. https://doi.org/10.1016/j.tiv.2016.03.009

Towards Creating the Perfect In Vitro Cell Model

Malin K. B. Jonsson, Toon A. B. van Veen, Jane Synnergren, Bruno Becker

Stem Cells International

2016. Artikel, editorial. https://doi.org/10.1155/2016/3459730 Open Access

Interactive visualization of large-scale gene expression data

Maria Riveiro, Mikael Lebram, Christian X. Andersson, Peter Sartipy, Jane Synnergren

Information Visualisation: Computer Graphics, Imaging and Visualisation

2016. Konferensbidrag. https://doi.org/10.1109/IV.2016.58

Transcriptional profiling of human embryonic stem cells during mesodermal- and cardiac differentiation

Jane Marie Synnergren, Caroline Améen, Karolina Åkesson, Alexander Karlsson, Maria Riveiro, Christian X. Andersson, Peter Sartipy

International Society for Stem Cell Research (ISSCR) Annual meeting, San Fransisco 22–25 June 2016

2016. Konferensbidrag, poster.

Comparative transcriptomic analysis identifies genes differentially expressed in human epicardial progenitors and hiPSC-derived cardiac progenitors

Jane Synnergren, Lauren Drowley, Alleyn T. Plowright, Gabriella Brolén, Marie-Josè Goumans, Adriana C. Gittenberger-de Groot, Peter Sartipy, Qing-Dong Wang

Physiological Genomics

2016. Artikel. https://doi.org/10.1152/physiolgenomics.00064.2016 Open Access

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

Patricio Godoy, Wolfgang Schmidt-Heck, Karthick Natarajan, Baltasar Lucendo-Villarin, Dagmara Szkolnicka, Annika Asplund, Petter Björquist, Agata Widera, Regina Stöber, Gisela Campos, Seddik Hammad, Agapios Sachinidis, Umesh Chaudhari, Georg Damm, Thomas S. Weiss et al.

Journal of Hepatology

2015. Artikel. https://doi.org/10.1016/j.jhep.2015.05.013 Open Access

Identification of stable reference genes in differentiating human pluripotent stem cells

Gustav Holmgren, Nidal Ghosheh, Xianmin Zeng, Yalda Bogestål, Peter Sartipy, Jane Synnergren

Physiological Genomics

2015. Artikel. https://doi.org/10.1152/physiolgenomics.00130.2014

Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells

Gustav Holmgren, Jane Synnergren, Yalda Bogestål, Caroline Améen, Karolina Åkesson, Sandra Holmgren, Anders Lindahl, Peter Sartipy

Toxicology

2015. Artikel. https://doi.org/10.1016/j.tox.2014.12.018 Open Access

Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes

Gustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson, Josefina Edsbagge

Drug Metabolism And Disposition

2014. Artikel. https://doi.org/10.1124/dmd.114.059154

Clinical Outcome 3 Years After Autologous Chondrocyte Implantation Does Not Correlate With the Expression of a Predefined Gene Marker Set in Chondrocytes Prior to Implantation but Is Associated With Critical Signaling Pathways

Johan Stenberg, Tommy S. de Windt, Jane Synnergren, Lars Hynsjö, Josefine van der Lee, Daniel B. F. Saris, Mats Brittberg, Lars Peterson, Anders Lindahl

The Orthopaedic Journal of Sports Medicine

2014. Artikel. https://doi.org/10.1177/2325967114550781 Open Access

Effects of interleukin-6 and interleukin-1β on expression of growth differentiation factor-5 and Wnt signaling pathway genes in equine chondrocytes

Emilia Svala, Anna I. Thorfve, Cecilia Ley, Helena K. Barreto Henriksson, Jane M. Synnergren, Anders H. Lindahl, Stina Ekman, Eva S. R. Skiöldebrand

American Journal of Veterinary Research

2014. Artikel. https://doi.org/10.2460/ajvr.75.2.132

Explore transcription factor profiles in human pluripotent stem cells

Jane Synnergren

6th International Conference on Bioinformatics and Computational Biology (BICoB 2014): Las Vegas, Nevada, USA, 24 – 26 March 2014

2014. Konferensbidrag.

Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor

Louise Sivertsson, Jane Synnergren, Janne Jensen, Petter Björquist, Magnus Ingelman-Sundberg

Stem Cells and Development

2013. Artikel. https://doi.org/10.1089/scd.2012.0202

Identification of miRNAs in Control of Aberrant Gene Transcription in Human Pluripotent Stem Cell Derived Hepatocytes

Jane Synnergren

Computer Applications in Industry and Engineering (CAINE-2013), 26th International Conference September 25-27, 2013, Los Angeles, California, USA

2013. Konferensbidrag.

Comparison of human cardiac gene expression profiles in paired samples of right atrium and left ventricle collected in vivo

Julia Asp, Jane Synnergren, Marianne Jonsson, Goran Dellgren, Anders Jeppsson

Physiological Genomics

2012. Artikel. https://doi.org/10.1152/physiolgenomics.00137.2011

High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart tissue

Lisa U. Magnusson, Annika Lundqvist, Julia Asp, Jane Synnergren, Cecilia Thalén Johansson, Lars Palmqvist, Anders Jeppsson, Lillemor Mattsson Hultén

Biochemical and Biophysical Research Communications - BBRC

2012. Artikel. https://doi.org/10.1016/j.bbrc.2012.06.117

MicroRNA regulatory network involved in impaired functionality in cardiomyocytes derived from human embryonic stem cells

Jane Synnergren

25th International Conference on Computer Applications in Industry and Engineering 2012 (CAINE-2012) Held with the 4th International Symposium on Sensor Network and Application (SNA-2012): New Orleans, Louisiana, USA 14-16 November 2012

2012. Konferensbidrag.

Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue

Jane Synnergren, Caroline Améen, Andreas Jansson, Peter Sartipy

Physiological Genomics

2012. Artikel. https://doi.org/10.1152/physiolgenomics.00118.2011

Transcriptional analysis of messenger-RNA and micro-RNA array data reveals global negative correlation in human stem cell derived cardiomyocyte clusters

Jane Synnergren, Peter Sartipy

4th International Conference on Bioinformatics and Computational Biology

2012. Konferensbidrag.

Expression of microRNAs and their target mRNAs in human stem cell-derived cardiomyocyte clusters and in heart tissue

Jane Synnergren, Caroline Améen, Anders Lindahl, Björn Olsson, Peter Sartipy

Physiological Genomics

2011. Artikel. https://doi.org/10.1152/physiolgenomics.00074.2010

Microarray Analysis of Undifferentiated and Differentiated Human Pluripotent Stem Cells

Jane Synnergren, Peter Sartipy

Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications

2011. Kapitel i bok.

Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity

Reha Yildirimman, Gabriella Brolén, Mireia Vilardell, Gustav Eriksson, Jane Synnergren, Hans Gmuender, Atanas Kamburov, Magnus Ingelman-Sundberg, Jose Castell, Agustin Lahoz, Jos Kleinjans, Joost van Delft, Petter Björquist, Ralf Herwig

Toxicological Sciences

2011. Artikel. https://doi.org/10.1093/toxsci/kfr225 Open Access

Human Embryonic Mesodermal Progenitors Highly Resemble Human Mesenchymal Stem Cells and Display High Potential for Tissue Engineering Applications

G.M. de Peppo, S. Svensson, M. Lennerås, Jane Synnergren, J. Stenberg, R. Strehl, J. Hyllner, P. Thomsen, C. Karlsson

Tissue Engineering. Part A

2010. Artikel. https://doi.org/10.1089/ten.TEA.2009.0629

Transcriptional profiling of human embryonic stem cells and their functional derivatives

Jane Synnergren

2010. Doktorsavhandling.

Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further towards the hepatic lineage

Jane Synnergren, Nico Heins, Gabriella Brolén, Gustav Eriksson, Anders Lindahl, Johan Hyllner, Björn Olsson, Peter Sartipy, Petter Björnquist

Stem Cells and Development

2010. Artikel. https://doi.org/10.1089/scd.2009.0220

Clustering micro-RNA array data using an information fusion based approach with multiple types of input data

Jane Synnergren, Alper Özdogan, Björn Olsson, Peter Sartipy

Proceedings of the ISCA 2nd International Conference on Bioinformatics and Computational Biology, BICoB-2010, March 24-26, 2010, Sheraton Waikiki Hotel, Honolulu, Hawaii, USA

2010. Konferensbidrag.

Regulation of 'stemness' and stem cell differentiation by microRNAs

P. Sartipy, Björn Olsson, J. Hyllner, Jane Synnergren

IDrugs. The Investigational Drugs Journal

2009. Artikel, forskningsöversikt.

Classification of information fusion methods in systems biology

Jane Synnergren, Björn Olsson, Jonas Gamalielsson

In Silico Biology

2009. Artikel, forskningsöversikt. https://doi.org/10.3233/ISB-2009-0391

Cardiomyogenic gene expression profiling of differentiating human embryonic stem cells

Jane Synnergren, Sudeshna Adak, Mikael Englund, Theresa Giesler, Karin Noaksson, Anders Lindahl, Patric Nilsson, Deirdre Nelson, Stewart Abbot, Björn Olsson, Peter Sartipy

Journal of Biotechnology

2008. Artikel. https://doi.org/10.1016/j.jbiotec.2007.11.011

A Data Integration Method for Exploring Gene Regulatory Mechanisms

Jane Synnergren, Björn Olsson, Jonas Gamalielsson

Conference on Information and Knowledge Management: Proceedings of the 2nd international workshop on Data and text mining in bioinformatics

2008. Konferensbidrag. https://doi.org/10.1145/1458449.1458468

Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells

Jane Synnergren, Karolina Åkesson, Kerstin Dahlenborg, Hilmar Vidarsson, Caroline Ameen, Daniella Steel, Anders Lindahl, Björn Olsson, Peter Sartipy

Stem Cells

2008. Artikel. https://doi.org/10.1634/stemcells.2007-1033

Mapping of the JDL data fusion model to bioinformatics

Jane Synnergren, Jonas Gamalielsson, Olsson Björn

2007 IEEE International Conference on Systems, Man and Cybernetics

2007. Konferensbidrag. https://doi.org/10.1109/ICSMC.2007.4414074

Differentiating human embryonic stem cells express a unique housekeeping gene signature

Jane Synnergren, Therese L. Giesler, Sudeshna Adak, Reeti Tandon, Karin Noaksson, Anders Lindahl, Patric Nilsson, Deirdre Nelson, Björn Olsson, Mikael C. O. Englund, Stewart Abbott, Peter Sartipy

Stem Cells

2007. Artikel. https://doi.org/10.1634/stemcells.2006-0247

Understanding the differentiation of human embryonic stem cells

Jane Synnergren

2006. Rapport.

Differentiating human embryonic stem cells express a unique housekeeping gene signature

Jane Synnergren, Therese L Giesler, Adak Sudeshna, Reeti Tandon, Karin Noaksson, Anders Lindahl, Patric Nilsson, Deidre Nelson, Björn Olsson, Mikael C O Englund, Stewart Abbot, Peter Sartipy

4th ISSCR Annual Meeting

2006. Konferensbidrag.

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