Institutionen för biovetenskap
Jane Synnergren is an Associate Professor at the University of Skövde, Sweden. She received her MSc in Computer Sciences from the University of Skövde in 2003 and started her graduate studies in bioinformatics in 2006. She recieved her PhD from University of Gothenburg in 2010. Her research interest is gene regulatory mechanisms that are important for stem cell differentiation. Working in close collaboration with the stem cell industry and the pharmaceutical industri she performs global expression studies of human pluripotent stem cells during their differentiation towards functional cell types, with a particular focus on heart-, liver- and neural cells. Results from her research have revealed gene expression patterns during the early phases of differentiation with potential importance for determining the fate of the stem cell. Results from recent studies have indicated important roles for miRNAs in the control of diverse aspects of heart formation and cardiac function. Her most recent research has been focused on identification of transcriptional biomarkers for toxic responses using hPSCs. She also performs research on epigenetic changes in hPSCs.
Classification of information fusion methods in systems biologySynnergren Jane, Olsson Björn, Gamalielsson JonasIn Silico Biology, 2009, 9(3), 65-76.
Regulation of 'stemness' and stem cell differentiation by microRNAs
Sartipy P., Olsson Björn, Hyllner J. et al.IDrugs. The Investigational Drugs Journal, 2009, 12(8), 492-496.
A Data Integration Method for Exploring Gene Regulatory MechanismsSynnergren Jane, Olsson Björn, Gamalielsson JonasConference on Information and Knowledge Management: Proceedings of the 2nd international workshop on Data and text mining in bioinformatics (81-84). ACM Press, 2008.
Cardiomyogenic gene expression profiling of differentiating human embryonic stem cells
Synnergren Jane, Adak Sudeshna, Englund Mikael et al.Journal of Biotechnology, 2008, 134(1-2), 162-170.
Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells
Synnergren Jane, Åkesson Karolina, Dahlenborg Kerstin et al.Stem Cells, 2008, 26(7), 1831-1840.
Differentiating human embryonic stem cells express a unique housekeeping gene signatureSynnergren Jane, Giesler Therese L., Adak Sudeshna et al.Stem Cells, 2007, 25(2), 473-480.
Mapping of the JDL data fusion model to bioinformatics
Synnergren Jane, Gamalielsson Jonas, Björn OlssonSystems, Man and Cybernetics, 2007. ISIC. IEEE International Conference on (2969-2974). IEEE Press, 2007.
Differentiating human embryonic stem cells express a unique housekeeping gene signatureSynnergren Jane, Giesler Therese L, Sudeshna Adak et al.4th ISSCR Annual Meeting. 2006.
Understanding the differentiation of human embryonic stem cells
Synnergren JaneSkövde: Institutionen för kommunikation och information, 2006. [Hämta fulltext]