Institutionen för biovetenskap
I am Associate Professor in bioinformatics at the University of Skövde, Sweden, and Head of the Translational Bioinformatics research group consisting of a group of 19 researchers with a dedicated interest in bioinformatics. I have a background in Data Science and received my MSc in Computer Sciences from the University of Skövde in 2003. During my graduate studies I developed my expertise in bioinformatics and large-scale omics data analysis and received my PhD from the University of Gothenburg in 2010.
My research is focused on analysis methods for identification of biomarkers and integration of multiple types of omics data. I am PI for several research projects specialized in stem cell differentiation, toxicity testing and disease modeling using stem cell based in vitro systems. I am also leading projects particularly focused on advanced analysis of big data, biomarker identification, and data integration with particular interest in machine-learning methods.
Working in close collaboration with the stem cell industry and the pharmaceutical industry we perform global expression studies including transcriptomics, proteomics, epigenomics, and metabolomics of human pluripotent stem cells during their differentiation towards functional cell types. The results from these studies have revealed mechanistic highlights during the early phases of stem cell differentiation and identified biomarkers with potential importance for applications in toxicity testing, drug development, and disease modeling.
Identification of miRNAs in Control of Aberrant Gene Transcription in Human Pluripotent Stem Cell Derived HepatocytesSynnergren JaneComputer Applications in Industry and Engineering (CAINE-2013), 26th International Conference September 25-27, 2013, Los Angeles, California, USA (11-16). International Society for Computers and Their Applications, 2013.
Comparison of human cardiac gene expression profiles in paired samples of right atrium and left ventricle collected in vivoAsp Julia, Synnergren Jane, Jonsson Marianne et al.Physiological Genomics, 2012, 44(1), 89-98.
Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue
Synnergren Jane, Ameen Caroline, Jansson Andreas et al.Physiological Genomics, 2012, 44(4), 245-258.
High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart tissue
Magnusson Lisa U., Lundqvist Annika, Asp Julia et al.Biochemical and Biophysical Research Communications - BBRC, 2012, 424(2), 327-330.
MicroRNA regulatory network involved in impaired functionality in cardiomyocytes derived from human embryonic stem cells
Synnergren Jane25th International Conference on Computer Applications in Industry and Engineering 2012 (CAINE-2012) Held with the 4th International Symposium on Sensor Network and Application (SNA-2012): New Orleans, Louisiana, USA 14-16 November 2012 (133-138). International Society for Computers and Their Applications, 2012.
Transcriptional analysis of messenger-RNA and micro-RNA array data reveals global negative correlation in human stem cell derived cardiomyocyte clusters
Synnergren Jane, Sartipy Peter4th International Conference on Bioinformatics and Computational Biology (178-183). Curran Associates, Inc., 2012.
Expression of microRNAs and their target mRNAs in human stem cell-derived cardiomyocyte clusters and in heart tissueSynnergren Jane, Améen Caroline, Lindahl Anders et al.Physiological Genomics, 2011, 43(10), 581-594.
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
Yildirimman Reha, Brolén Gabriella, Vilardell Mireia et al.Toxicological Sciences, 2011, 124(2), 278-290.
Microarray Analysis of Undifferentiated and Differentiated Human Pluripotent Stem Cells
Synnergren Jane, Sartipy PeterMethodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications (343-366). Rijeka, Croatia: INTECH, 2011.
Clustering micro-RNA array data using an information fusion based approach with multiple types of input dataSynnergren Jane, Özdogan Alper, Olsson Björn et al.Proceedings of the ISCA 2nd International Conference on Bioinformatics and Computational Biology, BICoB-2010, March 24-26, 2010, Sheraton Waikiki Hotel, Honolulu, Hawaii, USA (151-158). International Society for Computers and Their Applications, 2010.