Institutionen för biovetenskap
I am Associate Professor in bioinformatics at the University of Skövde, Sweden, and Head of the Bioinformatics research group consisting of a group of 13 researchers with a dedicated interest in bioinformatics. I have a background in Data Science and received my MSc in Computer Sciences from the University of Skövde in 2003. During my graduate studies I developed my expertise in bioinformatics and large-scale omics data analysis and received my PhD from the University of Gothenburg in 2010.
My research is focused on analysis methods for identification of biomarkers and integration of multiple types of omics data. I am PI for several research projects specialized in stem cell differentiation, toxicity testing and disease modeling using stem cell based in vitro systems. I am also leading projects particularly focused on advanced analysis of big data, biomarker identification, and data integration including machine-learning methods.
Working in close collaboration with the stem cell industry and the pharmaceutical industry we perform global expression studies including transcriptomics, proteomics, epigenomics, and metabolomics of human pluripotent stem cells during their differentiation towards functional cell types. The results from these studies have revealed mechanistic highlights during the early phases of stem cell differentiation and identified biomarkers with potential importance for applications in toxicity testing, drug development, and disease modeling.
MicroRNA regulatory network involved in impaired functionality in cardiomyocytes derived from human embryonic stem cellsSynnergren Jane25th International Conference on Computer Applications in Industry and Engineering 2012 (CAINE-2012) Held with the 4th International Symposium on Sensor Network and Application (SNA-2012): New Orleans, Louisiana, USA 14-16 November 2012 (133-138). International Society for Computers and Their Applications, 2012.
Transcriptional analysis of messenger-RNA and micro-RNA array data reveals global negative correlation in human stem cell derived cardiomyocyte clusters
Synnergren Jane, Sartipy Peter4th International Conference on Bioinformatics and Computational Biology (178-183). Curran Associates, Inc., 2012.
Expression of microRNAs and their target mRNAs in human stem cell-derived cardiomyocyte clusters and in heart tissueSynnergren Jane, Améen Caroline, Lindahl Anders et al.Physiological Genomics, 2011, 43(10), 581-594.
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
Yildirimman Reha, Brolén Gabriella, Vilardell Mireia et al.Toxicological Sciences, 2011, 124(2), 278-290.
Microarray Analysis of Undifferentiated and Differentiated Human Pluripotent Stem Cells
Synnergren Jane, Sartipy PeterMethodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications (343-366). Rijeka, Croatia: INTECH, 2011.
Clustering micro-RNA array data using an information fusion based approach with multiple types of input dataSynnergren Jane, Özdogan Alper, Olsson Björn et al.Proceedings of the ISCA 2nd International Conference on Bioinformatics and Computational Biology, BICoB-2010, March 24-26, 2010, Sheraton Waikiki Hotel, Honolulu, Hawaii, USA (151-158). International Society for Computers and Their Applications, 2010.
Human Embryonic Mesodermal Progenitors Highly Resemble Human Mesenchymal Stem Cells and Display High Potential for Tissue Engineering Applications
de Peppo G.M., Svensson S., Lennerås M. et al.Tissue Engineering. Part A, 2010, 16(7), 2161-2182.
Transcriptional profiling of human embryonic stem cells and their functional derivatives
Synnergren JaneDoktorsavhandling: Göteborgs universitet, 2010.
Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further towards the hepatic lineage
Synnergren Jane, Heins Nico, Brolén Gabriella et al.Stem Cells and Development, 2010, 19(7), 961-978.
Classification of information fusion methods in systems biologySynnergren Jane, Olsson Björn, Gamalielsson JonasIn Silico Biology, 2009, 9(3), 65-76.